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Table 2 Logistic regression analysis of factors predictive of positive findings on 18F–choline PET/CT. PSA, Gleason score and clinical local tumor stage were each analyzed as dichotomized variables, as a high-risk criterion or not. The percentage positive biopsy cores and the probability of lymph node metastasis according to the Briganti nomogram were analyzed as continuous variables with an odds ratio calculated for 10% increments. The area-under-the-curve for each univariate and multivariate model is shown to compare the models. For the multivariate models, the independent variables that were significant on univariate analyses were included. In model 1, the individual high-risk criteria were used, while in model 2 the sum of high-risk criteria were used. The risk of lymph node metastasis according to the Briganti nomogram was only analysed univariately, since it incorporates all the other variables

From: A population-based study of the clinical utility of 18F–choline PET/CT for primary metastasis staging of high-risk prostate cancer

 

Univariate

Multivariate model 1

Multivariate model 2

  

AUC = .76 (.68–.83)

AUC = .77 (.70–.85)

 

OR (95% CI)

p

AUC

OR (95% CI)

p

OR (95% CI)

p

PSA < vs ≥ 20 ng/ml

2.0 (1.0–4.0)

.05

.59 (.50–.69)

1.6 (0.8–3.5)

.198

  

GS < vs ≥ 8

1.9 (0.8–4.1)

.13

     

T < vs ≥ 3

2.7 (1.4–5.3)

.005

.61 (.51–.71)

1.8 (0.8–3.7)

.141

  

Proportion positive biopsy cores

1.4 (1.2–1.7)

<.001

.75 (.67–.83)

1.4 (1.2–1.6)

<.001

1.4 (1.1–1.6)

<.001

No. high-risk criteria

  

.68 (.58–.77)

    

1 (ref)

1

    

1

 

2

2.3 (1.0–5.0)

.043

   

1.7 (0.8–4.0)

.199

3

8.1 (3.1–21)

<.001

   

3.9 (1.4–11)

.010

Probability of N1a

1.5 (1.3–1.8)

<.001

.82 (.75–.88)

    
  1. OR odds ratio, CI confidence interval, PSA prostate specific antigen, T clinical local tumor stage, AUC area-under-the-curve
  2. aProbability of lymph node metastases according to the Briganti nomogram (Briganti et al., 2012)