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Table 1 Patient characteristics

From: Added value of 18F-FDG PET-CT in staging of Ewing sarcoma in children and young adults

Patient number

Stage of disease

Imaging modalities for comparison

SUVmax primary tumour

Discrepancy between conventional imaging and 18F-FDG PET-CT

Further imaging, biopsy, clinical follow-up

Added information from 18F-FDG PET-CT

1

localized

US/XR/CT/MRI /BS

3.0

no

no

2

localized

US /XR /CT /MRI /BS

2.2

no

no

3

metastatic

US /XR /CT

8.1

FDG positive lesion

CT confirm metastases

yes (true positive lesion)

4

localized

US /XR /CT /MRI /BS

20.8

no

no

5

localized

US /XR /CT /MRI /BS

7.2

FDG positive lesions

biopsy –benign histology

no (false positive lesions)

6

metastatic

US /XR /CT /MRI

17.0

no

no

7

localized

US /XR /CT /MRI /BS

3.8

FDG positive lesion

MRI and biopsy –benign histology

no (false positive lesion)

8

localized

US /XR /CT /MRI /BS

3.5

no

no

9

localized

US /XR /CT/ MRI

6.0

FDG positive lesion

clinical follow up –no development of metastases

no (false positive lesion)

10

localized

US /XR /CT /MRI /BS

7.0

no

no

11

metastatic

XR /CT /MRI /BS

4.0

no

no

12

metastatic

XR /CT /WB-MRI /BS

skeletal metastases on WB MRI, none on PET-CT or bone scan

no (false negative study)

13

metastatic

XR /CT /MRI /BS

4.4

FDG positive lesion

MRI confirm metastases

yes (true positive lesion)

14

localized

CT /MRI /BS

11.5

no

no

15

metastatic

US /XR /CT /MRI /BS

FDG positive lesion

clinical follow up - rapid progression of disease

yes (true positive lesion)

16

metastatic

XR /CT /MRI

FDG positive lesion

MRI confirm metastases

yes (true positive lesion)

17

metastatic

XR /CT /MRI / BS

4.3

no

no

18

localized

XR /CT / MRI /BS

12.6

no

no

19

localized

XR /CT /MRI /BS

no

no

  1. SUVmax  maximum standardized uptake value; US Ultrasound; XR radiography/X ray; CT Computed Tomography; MRI Magnetic Resonance Imaging; WB-MRI Whole Body Magnetic Resonance Imaging; BS bone scan; 18F-FDG PET-CT 18F Fluorodeoxyglucose Positron Emission Tomography Computed Tomography