Table 5 Patient-based results from meta-analyses and review studies on the detection of bone metastases in patients with prostate cancer
Modality | Study | Disease phase | N(s) N(pts) | Pooled sensitivity (%) | Pooled specificity (%) | Comments |
|---|---|---|---|---|---|---|
NaF-PET/CT | Evangelista et al. 2016 a | Mixed | 8 318 | 95.5 (CI: NA) | 77.4 (CI: NA) | One study was included with results for both NaF-PET and NaF-PET/CT (Even-Sapir et al. 2006) One study was included with lesion-based results (Poulsen et al. 2014) |
Wondergem et al. 2013 a | Mixed | 7 236 | 86.9 (CI: 83.7–90.0) | 79.9 (CI: 78.4–81.4) | One study was included with results of NaF-PET (Even-Sapir et al. 2006) | |
Choline-PET/CT | Evangelista et al. 2016 b | Relapse | 4 289 | 88.4 (CI: NA) | 96.6 (CI: NA) | 11C-choline studies only. One study was included with lesion-based results (Garcia et al. 2015) |
Shen et al. 2014 b | Mixed | 5 205 | 87 (CI: 79–93) | 97 (CI: 93–99) | Both 11C- and 18F-choline studies included | |
Wondergem et al. 2013 b | Mixed | 6 277 | 85.2 (CI: 83.8–86.6) | 96.5 (CI: 95.8–97.1) | Both 11C- and 18F-choline studies included | |
SPECT/CT | Evangelista et al. 2016 | Mixed | 1 97 | 96.4 (CI: NA) | 94.2 (CI: NA) | Only one study was included |
MRI | Woo et al. 2017 c | Mixed | 10 1031 | 96 (CI: 87–99) | 98 (CI: 93–99) | Mixed MRI protocols applied |
Evangelista et al. 2016 c | Mixed | 8 324 | 93.2 (CI: NA) | 96.6 (CI: NA) | Mixed MRI protocols applied | |
Shen et al. 2014 c | Mixed | 6 402 | 95 (CI: 90–98) | 96 (CI: 92–98) | Mixed MRI protocols applied |