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Table 1 Summary of studies utilizing F-18 FDG PET/CT in the evaluation of arterial inflammation in HIV-infected patients

From: Radionuclide imaging of inflammation in atherosclerotic vascular disease among people living with HIV infection: current practice and future perspective

Authors, year of publication

Number of HIV-infected patients

Vessels where TBR was obtained

Summary of findings

Comments

Subramanian et al. 2012

27

Ascending aorta

Higher TBR in HIV-infected patients than non-infected patients. TBR in HIV-infected patients comparable to TBR in non-HIV infected patients with atherosclerosis

 

Yarasheski et al. 2012

9

Carotid arteries

Aorta

TBR higher in HIV patients compared with non-HIV patients in the carotids but not in the aorta

 

Lo et al. 2015

40

Ascending aorta

No significant reduction in TBR was seen between HIV infected patients randomized to atorvastatin and HIV-infected patients treated with placebo

Technical difficulty hampered proper comparison of baseline scan and follow-up scan obtained after one year of treatment

Zanni et al. 2016

12

Ascending aorta

No significant change in TBR after 6 months of ART in treatment-naïve HIV-infected patients

Three of the study patients developed progression in coronary plaques as demonstrated on CCTA

Tawakol et al. 2017

45

Aorta

TBR was significantly higher in statin-naïve, HIV-infected patients on ART with undetectable viremia compared with matched (age, gender, and FRS) statin-naïve HIV-uninfected controls

 

Knudsen et al. 2015

26

Carotid, arteries, different regions of the aorta

No difference in TBR in all arterial beds between HIV infected and non-infected individuals.

 

Lawal et al. 2018

121

Ascending aorta

Higher aortic TBR in young individuals with HIV infections with otherwise low-risk for CVD compared with age and gender-matched HIV-uninfected controls

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