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Table 1 Summary of studies utilizing F-18 FDG PET/CT in the evaluation of arterial inflammation in HIV-infected patients

From: Radionuclide imaging of inflammation in atherosclerotic vascular disease among people living with HIV infection: current practice and future perspective

Authors, year of publication Number of HIV-infected patients Vessels where TBR was obtained Summary of findings Comments
Subramanian et al. 2012 27 Ascending aorta Higher TBR in HIV-infected patients than non-infected patients. TBR in HIV-infected patients comparable to TBR in non-HIV infected patients with atherosclerosis  
Yarasheski et al. 2012 9 Carotid arteries
Aorta
TBR higher in HIV patients compared with non-HIV patients in the carotids but not in the aorta  
Lo et al. 2015 40 Ascending aorta No significant reduction in TBR was seen between HIV infected patients randomized to atorvastatin and HIV-infected patients treated with placebo Technical difficulty hampered proper comparison of baseline scan and follow-up scan obtained after one year of treatment
Zanni et al. 2016 12 Ascending aorta No significant change in TBR after 6 months of ART in treatment-naïve HIV-infected patients Three of the study patients developed progression in coronary plaques as demonstrated on CCTA
Tawakol et al. 2017 45 Aorta TBR was significantly higher in statin-naïve, HIV-infected patients on ART with undetectable viremia compared with matched (age, gender, and FRS) statin-naïve HIV-uninfected controls  
Knudsen et al. 2015 26 Carotid, arteries, different regions of the aorta No difference in TBR in all arterial beds between HIV infected and non-infected individuals.  
Lawal et al. 2018 121 Ascending aorta Higher aortic TBR in young individuals with HIV infections with otherwise low-risk for CVD compared with age and gender-matched HIV-uninfected controls