Fig. 1
From: Does quantification have a role to play in the future of bone SPECT?
a–f According to one study, no statistically significant systematic differences were observed between results produced using planar whole-body bone scans, SPECT-CT, and PET-CT on newly diagnosed, high-risk prostate cancer (Fonager et al. 2017). But planar whole-body bone scans can lead to misclassifications. Fonager et al. described the following: ‘Anterior and posterior projections of the bone scan (a) were interpreted as non-metastatic on the dichotomous scale (with equivocal uptake in the pelvic region noted on the three-point scale). Both SPECT (b) and NaF PET (c) showed metastatic lesions on the maximum intensity projection images (long and short black arrows).’ (Images courtesy of e-Century PublishingCorporation, Wisconsin, USA)