ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging

EJNMMI Reports

Table 9 Summary of SUV-based sensitivity and specificity

	Constraints	Sample size	Positive group	Modality^a	AUC	SE^b	95% CI^c	z-statistic	Significance level P	Youden index J	95% Cl^d	Associated criterion (SUV)	95% CI^d
1)	None	228	82	xB	0.854	0.026	0.801–0.897	13.69	< 0.0001	0.538	0.423–0.597	> 11.63	8.6–17.1
1)	None	228	82	xQ	0.809	0.031	0.752–0.858	9.96	< 0.0001	0.529	0.399–0.627	> 9.4	8.54–12.32
2)	Not joints	120	63	xB	0.903	0.028	0.835–0.949	14.27	< 0.0001	0.698	0.555–0.780	> 9.86	8–11.63
2)	Not joints	120	63	xQ	0.864	0.034	0.780–0.919	10.68	< 0.0001	0.658	0.530–0.771	> 8.61	4.41–9.05
3)	Joints	108	19	xB	0.832	0.056	0.748–0.897	5.95	< 0.0001	0.640	0.437–0.790	> 13.42	9.25–13.87
3)	Joints	108	19	xQ	0.800	0.056	0.712–0.870	5.34	< 0.0001	0.584	0.373–0.734	> 9.4	9.18–9.47
4)	Not joints, CGAS volume ≤ 6 ml	45	29	xQ	0.812	0.063	0.668–0.913	5.00	< 0.0001	0.552	0.296–0.662	> 8.2	5.25–8.2
4)	Not joints, CGAS volume ≤ 6 ml	45	29	xB	0.877	0.053	0.745–0.956	7.16	< 0.0001	0.6467	0.400–0.806	> 9.11	6.90–11.29
5)	Not joints, CGZAS volume ≤ 6 ml	64	34	xQ	0.830	0.051	0.716–0.913	6.54	< 0.0001	0.529	0.294–0.624	> 8.41	5.14–8.41
5)	Not joints, CGZAS volume ≤ 6 ml	64	34	xB	0.868	0.045	0.760–0.939	8.13	< 0.0001	0.653	0.4290–0.8000	> 9.11	7.66–11.29
6)	Not joints, CGZAS volume ≥ 6 ml	56	29	xQ	0.941	0.034	0.843–0.986	12.85	< 0.0001	0.854	0.706–0.963	> 9.28	6.74–9.28
6)	Not joints, CGZAS volume ≥ 6 ml	56	29	xB	0.940	0.034	0.842–0.986	13.00	< 0.0001	0.852	0.633–0.926	> 9.86	8–11.63