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EJNMMI Reports
Fig. 3 | European Journal of Hybrid Imaging

Fig. 3

From: 18F-fluorothymidine (FLT)-PET and diffusion-weighted MRI for early response evaluation in patients with small cell lung cancer: a pilot study

Fig. 3

T-site (4-T) with high and heterogeneous FLT-uptake: FDG-PET (axial (a), coronal (b), sagittal (c)), FLT-PET (axial (d), coronal (e), sagittal (f)), and DW-MRI (transversal (g), coronal (h), sagittal (i)), and voxel-by-voxel scatterplot of FDG-SUV vs. FLT-SUV (j) and FLT-SUV vs. ADC (k). This lesion was clearly detectable on FDG-PET (SUVpeak 22.7), detectable but very heterogeneous on FLT-PET (SUVpeak 11.5), and detectable on DW-MRI (ADCmedian 1.43 × 10−3 mm2/s). The most metabolically active region (MTV70) was located caudally, whereas the most proliferative active region (PTV70) was located cranially within the tumor, thus MTV70 and PTV70 showed no overlap. The most water-diffusion restricted regions (DWTV50) were randomly distributed and overlapped partially with both MTV70 and PTV70. The voxel-by-voxel scatter plots (j, k) showed very weak overall correlations. This T-site had no change as response to chemotherapy

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