Table 1 Study and Clinicopathological characteristics of 13 included studies
| Â | Study characteristics | Clinicopathological characteristics | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Origin | Design | Endpoint | No. of patients | Age (year) | PSA (ng/mL) | Gleason score | Risk group | ||||
Author, publication year | Institution | Country | Enrollment period | Prospective | Multicenter | ||||||
Agrawal A, 2017 | TATA Memorial Hospital | India | NR | No | No | SVI | 35 | NR (47-73) | NR (NR) | NR (NR) | NR |
Berger I, 2018 | Nepean Hospital | Australia | Feb. 2015-Jan. 2017 | No | No | SVI | 50 | 64.9a (± 5.6) | 10.6a (± 8.1) | 7 [4 + 3] (6-9) | bLow, intermediate, high |
Dekalo S, 2019 | Tel-Aviv Sourasky Medical Center | Israel | NR | No | No | SVI | 59 | 65.35* (± 6.99) | 12.97a (11.88) | 7 [4 + 3] (7-9) | Intermediate, high |
Fendler WP, 2016 | Ludwig-Maximilians-University of Munich | Germany | Jan. 2014-April 2015 | No | No | SVI, EPE | 21 | 70.1a (± 5.9) | 58.7a (± 85.2) | 7 [4 + 3] (6-9) | High |
Gao J, 2019 | Drum Tower Hospital | China | Nov. 2017-Dec. 2018 | No | No | SVI, EPE | 49 | 69 (55-82) | 15.94 (4.04-72.05) | 7 [4 + 3] (7-8) | Intermediate, high |
Grubmuller B, 2018 | Medical University of Vienna | Austria | April 2014-July 2017 | Yes | No | SVI, EPE | 80 | 64 (59-71) | 7.63 (5.5-13.4) | 7 (6- > 8) | Intermediate, high |
Gupta M, 2018 | Rajiv Gandhi Cancer Institute and Research Centre | India | July 2014-March 2017 | No | No | SVI, EPE | 23 | 66 (38-88) | NR (≤ 10- > 20) | NR (6-10) | Intermediate, high |
Muehlematter UJ, 2019 | University Hospital Zurich | Switzerland | April 2016-July 2018 | No | No | SVI, EPE | 40 | 63a (± 6) | 8.12 (IQR 7.56) | 8 (7-9) | Intermediate, high |
Thalgot M, 2018 | Klinikum Rechts der Isar | Germany | Dec. 2012-Nov. 2015 | No | No | SVI, EPE | 73 | 68 (63-73) | 14.0 (6-35) | 8 (6-10) | High |
van Leeuwen PJ, 2019 | St Vincent’s Hospital, Netherlands Cancer Institute | Australia, Netherlands | Feb. 2015-Oct. 2017 | No | Yes | SVI | 140 | NR | 9.4 (NR) | 8 (7-9) | Intermediate, high |
von Klot CAJ, 2017 | Hannover Medical School | Germany | NR | No | No | SVI, EPE | 21 | 68 (56-77) | 11.9a (NR) | 7 [3 + 4] (6-10) | Intermediate, high |
Yilmaz B, 2019 | Istanbul Research and Training Hospital | Turkey | May 2016-April 2018 | No | No | SVI, EPE | 24 | 62.8a (± 6.4) | 12.0a (± 7.4) | 7 [4 + 3] (6-9) | bLow, intermediate, high |