Skip to main content

Table 2 PSMA-PET characteristics of 13 included studies

From: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) for local staging of prostate cancer: a systematic review and meta-analysis

Author, publication year Ligand Scanner vendor/model Mean dose (MBq) Uptake time (min) Acquisition time (min/bed) Furosemide Criteria for SVI or EPE Blinded reading Anatomical imaging MRI details Contrast-enhanced CT
Agrawal A, 2017 68Ga-PSMA-11 NR/NR NR NR NR NR None NR CT   NR
Berger I, 2018 68Ga-PSMA-11 Philips/Gemini TF 64 NR NR 1 h in total NR None Yes CT   NR
Dekalo S, 2019 68Ga-PSMA-11 GE/Discovery 690 NR (148-166.5) 45-60 4 NR None Yes CT   No
Fendler WP, 2016 68Ga-PSMA-11 Siemens/Biograph 64 TruePoint and GE/Discovery 690 *192 ± 48 (104-276) *58 ± 12 (45-80) NR Yes None Yes CT   Yes
Gao J, 2019 68Ga-PSMA-11 United Imaging/uMI 780 131.72 (130.6-177.6) 45 3 NR None No CT   No
Grubmuller B, 2018 68Ga-PSMA-11 Siemens/Biograph mMR 2/kg body weight 45 4 Yes EPE: T2WI assessment in PSMA-positive lesion
SVI: PSMA focus present in parts of seminal vesicles
Yes MRI 3 T, mp  
Gupta M, 2018 68Ga-PSMA-11 Siemens/Biograph TruePoint40 2/kg body weight NR 4 NR EPE: irregular prostate outline or extraprostatic structure involvement
SVI: increased uptake in seminal vesicles.
Yes CT   NR
Muehlematter UJ, 2019 68Ga-PSMA-11 GE/SIGNA *131 ± 18.8 (98-158) 60 15, prostate
2-3, rest of body
Yes MRI findings + abnormal uptake outside prostate or in seminal vesicle Yes MRI cMostly 3 T, bp  
Thalgot M, 2018 68Ga-PSMA-11 Siemens/Biograph mMR 138 (IQR, 114-156) 55 (IQR, 50-67) 15, prostate
5, rest of body
Yes EPE = MRI findings
SVI = MRI findings + uptake in seminal vesicle
Yes MRI 3 T, mp  
van Leeuwen PJ, 2019 68Ga-PSMA-11 Phillips/Ingenuity and Gemini a2.0/kg
b100
a60
b45
a3
b2 except for 3 in abdomen/pelvis
NR None Yes CT   Yes
von Klot CAJ, 2017 68Ga-PSMA-I&T Siemens/Biograph mCT *98 ± 25 (60-130) 60 min Continuous motion at 0.9 mm/s (chest-abdomen), 2.1 mm/s (leg) NR EPE: angulated contour of the prostate gland
SVI: none
Yes CT   No
Yilmaz B, 2019 68Ga-PSMA-11 Siemens/NR 175 (77-350) 60 min 3 NR EPE: none
SVI: visually as positive or negative
NR CT   
  1. BP Biparametric, CT Computed tomography, Ga Gallium, EPE Extraprostatic extension, MP Multi-parametric, MRI Magnetic resonance imaging, NR Not reported; PET Positron emission tomography; PSA Prostate-specific antigen, PSMA Prostate-specific membrane antigen, SVI Seminal vesical invasion
  2. *Data presented in mean ± standard deviation; others are presented in median and ranges
  3. aSt Vincent’s Hospital
  4. bNetherlands Cancer Institute
  5. c3 T performed in 36/40 patients and 1.5 T in 4/40