Table 2 PSMA-PET characteristics of 13 included studies
Author, publication year | Ligand | Scanner vendor/model | Mean dose (MBq) | Uptake time (min) | Acquisition time (min/bed) | Furosemide | Criteria for SVI or EPE | Blinded reading | Anatomical imaging | MRI details | Contrast-enhanced CT |
|---|---|---|---|---|---|---|---|---|---|---|---|
Agrawal A, 2017 | 68Ga-PSMA-11 | NR/NR | NR | NR | NR | NR | None | NR | CT | Â | NR |
Berger I, 2018 | 68Ga-PSMA-11 | Philips/Gemini TF 64 | NR | NR | 1 h in total | NR | None | Yes | CT |  | NR |
Dekalo S, 2019 | 68Ga-PSMA-11 | GE/Discovery 690 | NR (148-166.5) | 45-60 | 4 | NR | None | Yes | CT | Â | No |
Fendler WP, 2016 | 68Ga-PSMA-11 | Siemens/Biograph 64 TruePoint and GE/Discovery 690 | *192 ± 48 (104-276) | *58 ± 12 (45-80) | NR | Yes | None | Yes | CT |  | Yes |
Gao J, 2019 | 68Ga-PSMA-11 | United Imaging/uMI 780 | 131.72 (130.6-177.6) | 45 | 3 | NR | None | No | CT | Â | No |
Grubmuller B, 2018 | 68Ga-PSMA-11 | Siemens/Biograph mMR | 2/kg body weight | 45 | 4 | Yes | EPE: T2WI assessment in PSMA-positive lesion SVI: PSMA focus present in parts of seminal vesicles | Yes | MRI | 3 T, mp |  |
Gupta M, 2018 | 68Ga-PSMA-11 | Siemens/Biograph TruePoint40 | 2/kg body weight | NR | 4 | NR | EPE: irregular prostate outline or extraprostatic structure involvement SVI: increased uptake in seminal vesicles. | Yes | CT | Â | NR |
Muehlematter UJ, 2019 | 68Ga-PSMA-11 | GE/SIGNA | *131 ± 18.8 (98-158) | 60 | 15, prostate 2-3, rest of body | Yes | MRI findings + abnormal uptake outside prostate or in seminal vesicle | Yes | MRI | cMostly 3 T, bp |  |
Thalgot M, 2018 | 68Ga-PSMA-11 | Siemens/Biograph mMR | 138 (IQR, 114-156) | 55 (IQR, 50-67) | 15, prostate 5, rest of body | Yes | EPE = MRI findings SVI = MRI findings + uptake in seminal vesicle | Yes | MRI | 3 T, mp |  |
van Leeuwen PJ, 2019 | 68Ga-PSMA-11 | Phillips/Ingenuity and Gemini | a2.0/kg b100 | a60 b45 | a3 b2 except for 3 in abdomen/pelvis | NR | None | Yes | CT | Â | Yes |
von Klot CAJ, 2017 | 68Ga-PSMA-I&T | Siemens/Biograph mCT | *98 ± 25 (60-130) | 60 min | Continuous motion at 0.9 mm/s (chest-abdomen), 2.1 mm/s (leg) | NR | EPE: angulated contour of the prostate gland SVI: none | Yes | CT |  | No |
Yilmaz B, 2019 | 68Ga-PSMA-11 | Siemens/NR | 175 (77-350) | 60 min | 3 | NR | EPE: none SVI: visually as positive or negative | NR | CT |  |  |