Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma: comparison with 18F-FDG uptake

EJNMMI Reports

Table 2 Primary tumor semiquantitative PET parameters and p16 status data for the 28 patients with newly diagnosed oropharyngeal squamous cell carcinoma

PET parameter	p16 positive (n = 13)		p16 negative (n = 15)		P value
PET parameter	Mean	SD	Mean	SD	P value
¹¹C-4DST
SUVmax	7.79	1.48	9.10	2.64	0.066
Homogeneity	0.360	0.360	0.330	0.090	0.012
Entropy	2.078	0.177	2.058	0.273	0.857
SRE	0.942	0.014	0.950	0.037	0.005
LRE	1.272	0.077	1.241	0.240	0.009
LGZE	0.00634	0.00210	0.00499	0.00265	0.053
HGZE	241.08	101.89	346.99	172.82	0.042
¹⁸F-FDG
SUVmax	15.29	6.09	18.08	9.68	0.684
Homogeneity	0.253	0.062	0.305	0.177	0.822
Entropy	2.147	0.261	1.920	0.538	0.255
SRE	0.963	0.023	0.930	0.108	0.822
LRE	1.183	0.180	1.665	1.419	0.857
LGZE	0.00263	0.00177	0.00193	0.00131	0.619
HGZE	970.54	640.41	1134.29	799.85	0.651

SUVmax maximum standardized uptake value, SRE short-run emphasis, LRE long-run emphasis, LGZE low gray-level zone emphasis, HGZE high gray-level zone emphasis