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Table 2 Area under curve values with sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and diagnostic accuracy for important PET, perfusion, and diffusion parameters

From: Combined amino acid PET-MRI for identifying recurrence in post-treatment gliomas: together we grow

Parameter

AUC

CUT-OFF

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Diagnostic accuracy (%)

TBRmax

0.865

1.23

81.8

92.3

91.4

83.5

87.05

rCBVratio

0.823

1.38

84.8

76.9

78.6

83.5

80.85

ADCratio

0.776

1.11

78.1

69.2

71.7

75.9

73.65

ADCgrade

0.722

> 1

84

46.2

60.9

74.3

65.1

  1. TBR tumor to background ratio, SUV standard uptake value, rCBV relative cerebral blood volume, ADC apparent diffusion co-efficient, AUC area under the curve