Fig. 1

Subtraction SPECT coregistered to MRI (SISCOM). Patient #7 presented decreased rCBF in the anterior cingulate cortex (a), associated with recovered anxiety, addiction and psychosis after pulse therapy. Patient #10 presented increased rCBF in the right inferior parietal lobe (b) adjacent to a vasculitic insult (c), possibly due to luxury perfusion of the neighbouring cortex after treatment, and associated with the recovery of memory and hallucinations. Patient #12 presented increased rCBF in the precuneus, posterior cingulate cortex (d), and hypothalamus, associated with post-treatment persistent psychosis, aggressivity, and behaviour modification. Patient #14 presented two functional status after a left posterior cortex stroke: increased rCBF (e) (#14a) in the left medial occipital lobe (reperfusion) possibly related to post-treatment recovery from the hallucinations, and decreased rCBF (f) (#14b) in the posterior occipital lobe (worsening of ischemia). Patient #21 presented increased rCBF overlapping with the infarcted right basal ganglia (g), possibly representing luxury perfusion, and associated with the improvement in depressive symptoms