Patients characteristics | Total (n = 26) | Amelioration (n = 15, 57.69%) | Activation (n = 12, 46.15%) | Deactivation (n = 8, 30.77%) | Worsening (n = 6, 23.07%) | Binary logistic regression | Binary logistic regression | Mann-Whiney Test | |
---|---|---|---|---|---|---|---|---|---|
Amelioration and activation | Deactivation and worsening | ||||||||
Sex, female/male, n (%) | 19 (73.07)/7 (26.93) | 10 (66.67)/05 (33.33) | 08 (66.70)/04 (33.33)* | 05 (62.50)/03 (37.50) | 04 (66.67)/02 (33.33)** | * [X2(1) = 5.804; p = 0.041, R2 Negelkerke = 0.267] ** [X2(1) = 9.781; p = 0.008, R2 Negelkerke = 0.475] | NS | [X2(1) = 5.804; p = 0.041, R2 Negelkerke = 0.282] | – |
Age (years), mean (SD) | 43.19 | 44.13 | 40.91 | 43.48 | 43.03 | NS | NS | NS | – |
Race/ethnicity n (%) (Caucasians/non-Caucasians) | 17 (65.38)/09 (34.62) | 09 (60.00)/06 (40.00) | 08 (66.67)/04 (33.33) | 04 (50.00)/04 (50.00) | 04 (66.67)/02 (33.33)* | *[X2(1) = 8.119; p = 0.015, R2 Negelkerke = 0.406]c | NS | NS | – |
Age at SLE onset (mean, years) | 26.05 | 28.13 | 26.33 | 27.00 | 20.67 | – | – | – | NS |
Age at NPSLE onset (mean, years) | 42.29 | 46.83 | 42.08 | 43.25 | 47.83 | – | – | – | NS |
Interval between SLE and NPSLE first symptoms (mean, years) | 05.57 | 04.80 | 07.25 | 07.12 | 02.67 | – | – | – | NS |
SLEDAI, mean (SD) | 31.69 | 33.80 | 29.83 | 29.00 | 35.00 | – | – | – | NS |
SLICC/ACR-DI mean (SD) | 06.96 | 06.73 | 06.67 | 06.25 | 07.83 | – | – | – | NS |
Number of Pulse Therapies, mean (SD) | 09.23 | 08.80 | 09.92 | 09.50 | 08.33 | – | – | – | NS |
Normal MRI n (%) | 06 (23.07%)/20 (76.93) | 01 (06.67) | 05 (41.67) | 04 (50.00) | 00 (00.00) | – | – | – | – |
Abnormal MRI n (%) | 06 (23.07%)/20 (76.93) | 14 (93.33)# | 07 (58.33) | 04 (50.00)# | 06 (100.00) | – | – | – | – |
NP Manifestation n (%)*** | |||||||||
Psychosis | 17 (65.38) | 08 (53.33) | 10 (83.33) | 06 (75.00) | 03 (50.00) | NS | NS | NS | – |
Bipolar disorder | 01 (3.84) | 02 (13.33) | 00 (00.00) | 01 (12.50) | 01 (16.67) | NS | NS | NS | – |
Depression | 07 (26.92) | 03 (20.00) | 05 (41.67) | 03 (37.50) | 01 (16.67) | NS | NS | NS | – |
Vasculitis | 02 (7.69) | 02 (13.33) | 00 (00.00) | 00 (00.00) | 02 (33.33) | NS | NS | NS | – |
Seizure | 08 (30.77) | 04 (26.67) | 03 (25.55) | 02 (25.00) | 02 (33.33) | NS | NS | NS | – |
Anxiety | 06 (23.07) | 03 (20.00) | 03 (25.00) | 02 (25.00) | 02 (33.33) | NS | NS | NS | – |
Headache | 02 (7.69) | 01 (06.67) | 01 (08.33) | 01 (12.50) | 01 (16.67) | NS | NS | NS | – |
Epilepsy | 01 (3.84) | 01 (06.67) | 00 (00.00) | 00 (00.00) | 01 (16.67) | NS | NS | NS | – |
Stroke | 01 (3.84) | 01 (06.67) | 00 (00.00) | 00 (00.00) | 01 (16.67) | NS | NS | NS | – |
Autoantibodies—n (%) | |||||||||
Native anti-DNA reagent/not reagent | 13/13 (73.07/26.93) | 06 (40.00)/09 (60.00) | 08 (66.67)/04 (33.33) | 04 (50.00)/04 (50.00) | 02 (33.33)/04 (66.67) | NS | NS | NS | – |
ANA reagent/not reagent | 19/07 (73.07/26.93) | 10 (66.67)/05 (33.33) | 10 (83.33)/02 (16.67) | 06 (75.00)/02 (25.00) | 03 (50.00)/03 (50.00) | NS | NS | NS | – |
ACA IgG positive/negative (RV > 10 GPL/ml) | 09/13 (30.76/69.24) | 06 (37.50)/07 (46.67) | 04 (3.33)/06 (50.00) | 03 (37.50)/03 (37.50) | 02(33.33)/03(50.00) | NS | NS | NS | – |
ACA IgG not done | 04 (15.38) | 02 (13.33) | 02 (16.67) | 02 (25.00) | 01 (16.67) | – | – | – | – |
ACA IgM positive/negative (RV > 7 MPL/ml) | 12/14 (46.15/53.85) | 09 (60.00)/04 (26.67) | 06 (50.00)/03 (25.00) | 02 (25.00)/04 (50.00) | 02(33.33)/03(50.00) | NS | NS | NS | – |
ACA IgM not done | 04 (15.38) | 02 (13.33) | 03 (25.00) | 02 (25.00) | 01 (16.67) | – | – | – | – |
P2GPI IgG positive/negative (RV > 5 GPL/ml) | 05/11 (31.25/68.75) | 04 (26.67)/06 (40.00) | 02 (16.67)/08 (66.67) | 02(25.00)/03(37.50) | 01(16.67)/04(66.67) | NS | NS | NS | – |
P2GPI IgG not done | 10 (38.46) | 05 (33.33) | 02 (16.67) | 03 (37.50) | 01(16.67) | – | – | – | – |
P2GPI IgM positive/negative (RV > 5 MPL/ml) | 07/09 (43.75/56.25) | 06 (40.00)/04 (26.67) | 04 (33.33)/06(50.00) | 01 (12.50)/03(37.50) | 01 / 04(66.67) | NS | NS | NS | – |
P2GPI IgM not done | 10 (38.46) | 05 (33.33) | 02 (16.67) | 04 (50.00) | 01(16.67) | – | – | – | – |
SS-B (LA) positive/negative (RV > 20 U/ml) | 01/06 (14.29/85.71) | 01 (06.67)/06 (40.00) | 00 (00.00)/05 (41.67) | 00 (00.00)/05 (50.00) | 01 (16.67)/01 (16.67) | NS | NS | NS | – |
SS-B (LA) not done | 19 (73.08) | 08 (53.33) | 07 (58.33) | 07 (87.50) | 04 (66.67) | – | – | – | – |
SS-A (RO) positive/negative (RV > 80 U/ml) | 03/07 (30.00/70.00) | 02 (13.33)/08 (53.33) | 00 (00.00)/06 (50.00) | 01 (12.50)/04 (50.00) | 00 (00.00)/02 (33.33) | NS | NS | NS | – |
SS-A (RO) not done | 16 (61.53) | 05 (33.33) | 06 (50.00) | 03 (37.50) | 04 (66.67) | – | – | – | – |
Complement—n(%) | |||||||||
C3 normal (RV 0.9–1.4 U/ml) | 16 (61.50) | 09 (60.00)* | 07 (58.33) | 02 (25.00) | 06 (100.00) | *[X2(1) = 6.168; p = 0.021, R2 Negelkerke = 0.303] | NS | NS | – |
C3 altered / not done | 08 (30.76)/02 (07.69) | 03/02 (13.33) | 05 (41.67)/00 (00.00) | 06 (75.00)/00 (00.00) | 00 (00.00)/00 (00.00) | – | – | – | – |
C4 normal (RV 0.1–0.4 U/ml) | 16 (61.50) | 10 (66.67) | 07 (58.33) | 06 (75.00) | 04 (66.67) | NS | NS | NS | – |
C4 altered / not done | 08 (30.76)/02 (07.69) | 04 (26.67)/01 (06.67) | 05 (41.67)/00 (00.00) | 02 (25.00)/00 (00.00) | 02 (33.33) | – | – | – | – |