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Table 2 Brain regions of significant rCBF changes in CLBP patients

From: Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study

Brain regions

p*

Cluster volume (k)

Talairach coordinates x, y, z

Maximum voxel Z score

Increased rCBF

    

Cluster A—R Occipital Lobe (Calcarine, Cuneus, Lingual, Middle Occipital Gyri),

R Posterior Cingulate Gyrus

0.023

733

20, − 70, 4

4.35

Cluster B—R Frontal Lobe (Middle and Inferior Frontal Gyri), R anterior (BA 10), and dorsolateral (BA 46) prefrontal cortex

0.032

660

36, 44, 18

4.14

Decreased rCBF

    

Cluster C—L Parietal Lobe (Precuneus, Paracentral Lobe),

R Parietal Lobe (Postcentral Gyrus, Paracentral Lobe) (BA 5 and 7) and R middle Cingulate Gyrus

0.000

2,774

0, − 52, 68

1.84

  1. *p value of cluster significance; R right; L left; BA Brodmann Area