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Table 2 Rare metastatic (RM) lesions' characteristics with laboratory details

From: Rare sites of metastases in patients with differentiated thyroid carcinoma and added value of SPECT/CT over planar whole body radioactive iodine scan

Cases

RM site

RM appearance time

RM symptoms

TM before RM treatment (ng/ml)

 

TM after RM treatment (ng/ml)

RM imaging

RM treatment

1

Kidney and pancreas

Synchronous

No

Tg

AntiTg

2320

1.87(negative)

285

0.9

Fu WBIs

CT

MRI

RAIT

2

Sella turcica

Synchronous

Diminution of vision

Tg

AntiTg

 > 500

0.2

3544

 < 15 (negative)

PT WBIs

MRI

RAIT + Brain RTH

3

Muscle

Metachronous (4 years After thyroidectomy)

Neck swelling

Tg

AntiTg

964

26.5 (negative)

 > 500

13.5 (negative)

Fu WBIs

PET/CT

RAIT

4

Parapharyngeal mass

Synchronous

Neck swelling

Tg

AntiTg

3.26

267 (positive)

0.18

20 (positive)

PT WBIs

MRI

RAIT

5

Solitary bone (Iliac mass)

Metachronous (5 years After thyroidectomy)

Iliac mass

Tg

AntiTg

 > 3000

0.5

 > 300

55 (negative)

Fu WBIs

CT

MRI

RAIT + RTH

6

Solitary brain

Metachronous (1 year After thyroidectomy)

Headache

Tg

AntiTg

 > 2500

385 (positive)

 > 500

337

Fu WBIs

MRI

RAIT + Brain RTH

7

Bone metastasis from PTC

Synchronous

Dorsal mass

Tg

AntiTg

57

105 (positive)

2.14

207

Fu WBIs

CT

RAIT + RTH

8

Eye and liver

Metachronous (20 years after thyroidectomy)

Flashes of light Black spot in visual field

Tg

AntiTg

Unknown

Unknown

Fu WBIs

Ocular CT

PET/CT

RAIT

9

IJV malignant thrombosis

Synchronous

No

Tg

AntiTg

1867.5

0.5

7.5

19.5 (negative)

Fu WBIs

Colored Doppler

RAIT + excision

10

Bone metastasis from PTC

Synchronous

Shoulder swelling

Tg

AntiTg

 > 500

15(negative)

11

(negative)

PT WBIs

CT

RAIT + RTH

11

Renal

Metachronous 2 years after thyroidectomy)

Neck swelling

Tg

AntiTg

965

0.78(negative)

4000

(negative)

Fu WBIs

MRI

RAIT

12

Brain

Synchronous

Headache

Brain SOL

Tg

AntiTg

1278 0.7(negative)

930 (negative)

Fu WBIs

MRI

RAIT + Brain RTH excision

13

Brain and liver

Synchronous

Headache

HFL and Brain SOL

Tg

AntiTg

9400

10 (negative)

13,888 (negative)

Fu WBIs

MRI

Abdominal US

RAIT + Brain RTH

14

Parapharyngeal

Synchronous

Neck swelling

Tg

AntiTg

197

17.8(negative)

0.84

(negative)

PT WBIs

RAIT

15

Endotracheal

Metachronous (4 years after thyroidectomy)

Dyspnea

Tg

AntiTg

186

10.37(negative)

7120

(negative)

PT WBIs

MRI

PET/CT

RAIT + RTH + CTH

  1. RM rare metastasis, TM tumor marker, Tg Thyroglobulin, AntiTg anti-thyroglobulin antibodies, Fu WBIs follow-up whole body iodine-131 scan, PT WBIs post-therapy whole body iodine-131 scan, RAIT radioactive iodine-131 therapy, RTH radiotherapy