Quantitative assessment of PSMA PET response to therapy in castration-sensitive prostate cancer using an automated imaging platform for disease identification and measurement

Duriseti, Sai; Berenji, Gholam; Tsai, Sonny; Rettig, Matthew; Nickols, Nicholas G.

doi:10.1186/s41824-023-00165-6

EJNMMI Reports

Table 1 Patient clinicopathologic data and treatment course

From: Quantitative assessment of PSMA PET response to therapy in castration-sensitive prostate cancer using an automated imaging platform for disease identification and measurement

Patient number	Disease timing	miTNM at diagnosis	Prostate/bed disease	Regional nodal disease	Non-regional Nodal diseaseˤ	Osseous disease	Imaging interval (months)	Interval treatment	% reduction in PSA
1	De novo	T3bN1bM0	Yes	Yes	No	No	30	ADT + radiotherapy	100
2	De novo	T2mN0M1b	Yes	No	No	Yes	14	Surgery + ADT + radiotherapy	100
3	De novo	T2uN0M0	Yes	No	No	No	13	Surgery	84
4	Recurrence	T2mN1bM0	Yes	Yes	No	No	10	ADT + radiotherapy	99
5	De novo	T2mN1bM1b	Yes	Yes	No	Yes	21	ADT + radiotherapy	100
6	Recurrence	T2mN0M1b	Yes	No	No	Yes	3	ADT + radiotherapy	100
7	De novo	T2mN1aM0	Yes	Yes	No	No	3	Surgery	92
8	De novo	T3bN1aM1a	Yes	Yes	Yes	No	20	Surgery + ADT + radiotherapy	95
9	De novo	T3bN1bM1a	Yes	Yes	Yes	No	21	Surgery + ADT	92
10	De novo	T3aN1aM1b	Yes	Yes	No	Yes	11	ADT + radiotherapy	100
11˘	Recurrence	T0N0M1b	No	No	Yes	Yes	12	ADT + radiotherapy	100
12^˜	Recurrence	T0N1aM0	No	Yes	No	No	12	Unknown˜	Unknown˜
13	De novo	T3bN1bM1b	Yes	Yes	Yes	Yes	4	ADT	69
14 ^ˠ	De novo	T3bN1bM1b	Yes	Yes	No	Yes	5	ADT + radiotherapy	100
15	De novo	T3bN0M1b	Yes	Yes	Yes	Yes	7	ADT + radiotherapy	83
16	De novo	T3bN1bM1b	Yes	Yes	No	Yes	7	ADT + radiotherapy	98
17˘	Recurrence	TrN1bM1b	Yes	Yes	No	Yes	15	ADT + radiotherapy	100
18	De novo	T2uN1aM1b	Yes	Yes	No	Yes	26	Surgery + ADT + radiotherapy	100
19	De novo	T3bN1bM1b	Yes	Yes	No	Yes	7	ADT + radiotherapy	100
20	De novo	T2mN1aM1b	Yes	Yes	No	Yes	7	ADT + radiotherapy	100
21	De novo	T3bN1aM1b	Yes	Yes	No	Yes	7	ADT + radiotherapy	100
22	De novo	T2mN1aM0	Yes	Yes	No	No	7	ADT + radiotherapy	100
23	De novo	T2mN1bM1a	Yes	Yes	Yes	No	7	ADT + radiotherapy	100
24	De novo	T3bN1bM1b	Yes	Yes	No	Yes	18	ADT + radiotherapy	100
25	De novo	T2mN0M1b	Yes	No	No	Yes	9	ADT + radiotherapy	100
26	De novo	T2mN1aM0	Yes	Yes	No	Yes	6	ADT + radiotherapy	99
27	De novo	T2mN0M1b	Yes	No	No	Yes	7	ADT + radiotherapy	100
28˘	Recurrence	T0N1bM1a	No	Yes	Yes	No	7	ADT	100
29	De novo	T2mN1bM1a	Yes	Yes	Yes	No	8	ADT + radiotherapy	100
30	De novo	T2mN1bM1a	Yes	Yes	Yes	No	7	ADT + radiotherapy	97

˘Patients with recurrent disease who had undergone prior prostatectomy
˜Patient 12’s treatment course and PSA response was not available for review
ˠPatient 14 had concurrent lung metastases at initial PSMA PET-CT
ˤNon-regional nodal disease was any nodal disease above the bifurcation of the common iliac arteries

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