Skip to main content

Table 1 Clinical and functional data for patients at baseline

From: Assessment of 18F-FDG uptake in idiopathic pulmonary fibrosis: influence of lung density changes

Characteristics Patients (n = 31) Progressive (n = 15) Non-progressive (n = 14) p value
Age (years, mean ± SD) 69.8 ± 8.6 70.0 ± 9.0 68.6 ± 8.6 p = NS
Sex ratio (M/F) (n) 23/8 12/3 9/5 p = NS
Smoking status (n)
 Never smoker 4 2 2  
 Current smoker 0 0 0  
 Former smoker 25 12 11  
 Passive smoker 2 1 1  
Treatments (n)
 Pirfenidone 15 7 7  
 Nintedanib 15 8 6  
 No treatments 1 0 1  
GAP score (n)
 Stage 1 10 2 8  
 Stage 2 16 8 6  
 Stage 3 5 5 0  
C-reactive protein (mg/L) (median, range) 3.2 (1.9–7) 2.7 (1.7–5.6) 3.75 (1.72–8.2) p = NS
Pulmonary function test (mean ± SD):
 FVC (% predicted) 73.9 ± 19.0 64.4 ± 13.5 83.8 ± 19.9 p = 0.005 *
 DLCO (% predicted) 44.3 ± 11.7 41.5 ± 14.4 47.1 ± 8.3 p = NS
6MWT (n = 28) (mean ± SD)
 SaO2 post-exercise (%) 89.1 ± 4.7 87.3 ± 4.0 90.9 ± 4.2 p = 0.035 *
 Distance traveled (m) 464.4 ± 111.7 464.8 ± 118.4 460.4 ± 114.8 p = NS
Bronchoalveolar lavage cytology (n = 24) (median, range)
 Cellularity (/mm3) 293 (140–450) 405 (130–567.5) 261.5 (132.5–420) p = NS
 Macrophages (%) 79 (65–89) 85.5 (60.2–92) 79 (65–85) p = NS
 Lymphocytes (%) 4 (2.5–7) 3.5 (1.75–7) 5.5 (2.5–10) p = NS
 Neutrophils (%) 8 (3–15) 6 (3.75–10) 8 (2–16) p = NS
 Eosinophils (%) 1 (0–3) 1 (0–9.5) 2 (0–3) p = NS
PET/CT parameters (mean ± SD)
 SUVmean uncorr 0.95 ± 0.19 1.00 ± 0.20 0.89 ± 0.17 p = NS
 SUVmax uncorr 3.24 ± 0.73 3.34 ± 0.92 3.12 ± 0.52 p = NS
 SUVmean corr 2.70 ± 0.35 2.72 ± 0.43 2.65 ± 0.29 p = NS
 SUVmax corr 29.89 ± 6.43 30.20 ± 6.74 30.48 ± 6.26 p = NS
CT mean (HU) (mean ± SD) −580.04 ± 57.34 − 563.09 ± 51.78 − 598.49 ± 61.51 p = NS
  1. p is the value of unpaired Student t tests or Mann-Whitney test for simple comparisons between two groups (progressive vs. non-progressive disease)
  2. NS not significant, SD standard deviation, FVC Forced vital capacity, DLCO carbon monoxide diffusion, 6MWT 6-min walking test, SaO2 oxygen saturation, SUV standardized uptake value