ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging

EJNMMI Reports

Table 10 Comparison of ROC’s: area under the curve (AUC)

	Constraints	Sample size	Positive group	Negative group	SUV lesion average of reconstruction modality	AUC	SE^a	95% CI^b
1)	None	228	82	146	CGAS_Ave	0.809	0.0311	0.752–0.858
					CGZAS	0.855	0.0256	0.803–0.898
					CGZAS_Ave	0.854	0.0258	0.801–0.897
2)	Joints	108	19	89	CGAS_Ave	0.8	0.0561	0.712–0.870
2)	Joints	108	19	89	CGZAS_Ave	0.832	0.0558	0.748–0.897
3)	Not joints, CGAS Volume ≤ 6 ml	45	29	16	CGAS_Ave	0.812	0.0625	0.668–0.913
3)	Not joints, CGAS Volume ≤ 6 ml	45	29	16	CGZAS_Ave	0.877	0.0527	0.745–0.956
4)	Not Joints, CGZAS volume ≤ 6 ml	64	34	30	CGAS_Ave	0.83	0.0505	0.716–0.913
4)	Not Joints, CGZAS volume ≤ 6 ml	64	34	30	CGZAS_Ave	0.868	0.0452	0.760–0.939
5)	Not Joints, CGZAS volume ≥ 6 ml	56	29	27	CGAS_Ave	0.941	0.0343	0.843–0.986
5)	Not Joints, CGZAS volume ≥ 6 ml	56	29	27	CGZAS_Ave	0.94	0.0338	0.842–0.986
Pairwise comparison of ROC’s: SUV-based lesion assessment
	Constraints	SUV lesion average of reconstruction modality	Difference between areas	SE^a	95% CI^b	z-statistic	Significance level
1)	None	CGAS_Ave ~ CGZAS	0.046	0.015	0.016–0.076	2.97	p = 0.0030
		CGAS_Ave ~ CGZAS_Ave	0.045	0.013	0.019–0.070	3.394	p = 0.0007
		CGZAS ~ CGZAS_Ave	0.0012	0.009	− 0.016-0.018	0.137	p = 0.8912
2)	Joints	CGAS_Ave ~ CGZAS_Ave	0.033	0.017	0.0003–0.07	1.977	p = 0.0480
3)	Not joints, CGAS volume ≤ 6 ml	CGAS_Ave ~ CGZAS_Ave	0.065	0.034	− 0.003-0.132	1.881	p = 0.0600
4)	Not joints, CGZAS volume ≤ 6 ml	CGAS_Ave ~ CGZAS_Ave	0.037	0.026	− 0.014-0.09	1.431	p = 0.1525
5)	Not joints, CGZAS volume ≥ 6 ml	CGAS_Ave ~ CGZAS_Ave	0.0006	0.007	− 0.014-0.015	0.0861	p = 0.9314