Incorporation of CAD (computer-aided detection) with thin-slice lung CT in routine 18F-FDG PET/CT imaging read-out protocol for detection of lung nodules

EJNMMI Reports

Table 1 Performance of three readers with regards to the reading time required and number of nodules detected using different imaging techniques

	Reader 1	Reader 2	Reader 3	Average
Experience	> 15 years	10 years	1 year
Mean reading time in seconds
FDG PET	16.42	17.53	40.94	24.96
lCT	23.14	23.85	45.62	30.87
dCT	39.61	43.6	96.58	59.93
CADs	33.61	27.78	58.81	40.07
Number of nodules detected
FDG PET	39	42	41	40.67
lCT	112	130	121	121
dCT	275	300	276	283.67
CADs	292	306	249	282.33
Extra nodules by CAD	62	54	32	49.33
Nodules missed by CAD	45	52	62	53
Time for CADp	8.3	8.3	8.3	8.3
CADp nodules	1967	1967	1967	1967
Accepted nodules	292	306	249	282.33
Rejected nodules (Fps)	1678	1661	1718	1685.67
FP rate per scan	16.8	16.6	17.2	16.8

FDG PET 18F-fluorodeoxyglucose positron emission tomography, lCT Low-dose computed tomography, dCT diagnostic lung CT, CADp Computer-aided detection (primary reading), CADs Computer-aided detection (secondary reading), FP False positive