Incorporation of CAD (computer-aided detection) with thin-slice lung CT in routine 18F-FDG PET/CT imaging read-out protocol for detection of lung nodules

EJNMMI Reports

Table 5 ROC AUC Analysis for four different imaging techniques for diagnosis of lung metastases

	AUC	95% confidence interval
Reader 1
FDG PET	0.712	(0.618, 0.806)
lCT	0.783	(0.693, 0.874)
dCT	0.786	(0.727, 0.844)
CADs	0.788	(0.716, 0.861)
Reader 2
FDG PET	0.729	(0.634, 0.823)
lCT	0.800	(0.713, 0.887)
dCT	0.771	(0.713, 0.830)
CADs	0.805	(0.739, 0.870)
Reader 3
FDG PET	0.719	(0.626, 0.812)
lCT	0.845	(0.766, 0.925)
dCT	0.793	(0.735, 0.851)
CADs	0.805	(0.739, 0.870)
Overall, with all three readers combined:
FDG PET	0.720	(0.666, 0.773)
lCT	0.810	(0.760, 0.859)
dCT	0.783	(0.750, 0.817)
CADs	0.799	(0.760, 0.838)

ROC AUC Analysis (area under the receiver operating characteristic curve) for four different imaging techniques for diagnosis of lung metastases
PET 18F-FDG positron emission tomography, lCT low-dose CT, dCT diagnostic lung CT, CADs Computer-aided detection (secondary reading)