Table 3 PSMA-PET metrics and PSA outcomes
Total | PSA progression at PET2 | No PSA progression at PET2 | P value | |
|---|---|---|---|---|
Total, n (%) | 35 (100) | 9 (25.7) | 26 (74.3) | N/A |
Castration status, n (%) | 0.304 | |||
Castration-sensitive, n (%) | 29 (82.9) | 9 (100) | 20 (76.9) | |
Castration-resistant, n (%) | 6 (17.1) | 0 (0) | 6 (23.1) | |
miTNM Stage (PET1–PET2) | 0.007 | |||
Upstaged, n (%) | 8 (22.9) | 5 (55.6)* | 3 (11.5) | |
Downstaged/no change, n (%) | 27 (77.1) | 4 (44.4) | 23 (88.5) | |
Baseline WB-PSMA-VOL | 0.009 | |||
Above median, n (%) | 18 (51.4) | 8 (88.9)* | 10 (38.5) | |
Below median, n (%) | 17 (48.6) | 1 (11.1) | 16 (61.5) | |
Changes in WB-PSMA-VOL | 0.058 | |||
≥ 20%, n (%) | 5 (14.3) | 3 (33.3) | 2 (7.7) | |
< 20%, n (%) | 30 (85.7) | 6 (66.7) | 24 (92.3) | |
New Lesions on PET2 | < .001 | |||
Yes, n (%) | 9 (25.7) | 7 (77.8)* | 2 (7.7) | |
No, n (%) | 26 (74.3) | 2 (22.2) | 24 (92.3) | |
RECIP 1.0 | 0.058 | |||
PD, n (%) | 5 (14.3) | 3 (33.3) | 2 (7.7) | |
Non-PD, n (%) | 30 (85.7) | 6 (66.7) | 24 (92.3) | |
Baseline WB-PSMA-SUVmean | 0.009 | |||
Above median, n (%) | 18 (51.4) | 8 (88.9)* | 10 (38.5) | |
Below median, n (%) | 17 (48.6) | 1 (11.1) | 16 (61.5) | |
Changes in WB-PSMA-SUVmean | 0.238 | |||
≥ 30%, n (%) | 4 (11.4) | 2 (22.2) | 2 (7.7) | |
< 30%, n (%) | 31 (88.6) | 7 (77.8) | 24 (92.3) |