Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study

Mazini, Bianca; Dietz, Matthieu; Maréchal, Bénédicte; Corredor-Jerez, Ricardo; Prior, John O.; Dunet, Vincent

doi:10.1186/s41824-023-00180-7

EJNMMI Reports

Table 3 MRI-derived brain morphometry quantitative data

From: Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study

Parameters	Normal perfusion N = 51	Small-vessel disease N = 12	P value
Brain	− 0.82 ± 1.75	− 1.13 ± 1.34	0.29
Total GM	− 0.70 ± 1.99	− 0.75 ± 1.09	0.44
Cortical GM	− 0.67 ± 1.82	− 0.67 ± 1.12	0.62
Right frontal GM	− 0.84 ± 1.58	− 0.83 ± 1.07	0.93
Left frontal GM	− 0.73 ± 1.51	− 0.75 ± 0.89	0.71
Right temporal GM	− 0.43 ± 1.65	− 0.26 ± 1.09	0.85
Left temporal GM	− 0.73 ± 1.73	− 0.74 ± 1.69	1.0
Right parietal GM	− 0.40 ± 1.74	− 0.50 ± 1.19	0.72
Left parietal GM	− 0.32 ± 1.45	− 0.56 ± 1.10	0.37
Right occipital GM	0.04 ± 1.23	0.24 ± 0.69	0.88
Left occipital GM	0.13 ± 1.18	− 0.02 ± 0.57	0.39
Right hippocampus	0.35 ± 1.09	0.63 ± 1.41	0.53
Left hippocampus	− 0.08 ± 1.21	0.59 ± 1.44	0.14
Right-caudate nucleus	0.38 ± 1.35	0.45 ± 1.19	0.85
Left-caudate nucleus	0.15 ± 1.23	0.42 ± 1.16	0.39
Right putamen	− 0.27 ± 1.38	− 0.31 ± 1.42	0.87
Left putamen	− 0.36 ± 1.34	− 0.47 ± 1.10	0.76
Right pallidum	0.03 ± 1.26	0.05 ± 1.28	0.91
Left pallidum	− 0.18 ± 1.30	− 0.49 ± 0.71	0.44
Right thalamus	0.18 ± 1.20	0.15 ± 1.45	0.85
Left thalamus	0.02 ± 1.19	0.15 ± 1.46	0.90
Total GMab (mL)	0.28 ± 0.10	0.33 ± 0.12	0.09
Total WM	− 0.40 ± 1.47	− 0.72 ± 1.09	0.32
Right frontal WM	− 0.82 ± 1.14	− 1.76 ± 1.29	0.024
Left frontal WM	− 0.63 ± 1.11	− 1.59 ± 1.30	0.021
Right temporal WM	− 0.33 ± 1.53	− 0.68 ± 1.42	0.56
Left temporal WM	− 0.44 ± 1.35	− 0.73 ± 1.63	0.68
Right parietal WM	− 0.43 ± 1.16	− 0.89 ± 1.00	0.15
Left parietal WM	− 0.36 ± 1.05	− 0.71 ± 1.24	0.42
Right occipital WM	0.09 ± 1.44	− 0.01 ± 1.00	0.49
Left occipital WM	0.14 ± 1.27	0.18 ± 0.74	0.93
Total WMab (mL)	3.54 ± 6.61	4.75 ± 11.9	0.58
Mesencephalon	− 0.19 ± 1.27	− 0.43 ± 1.11	0.60
Pons	− 0.13 ± 0.95	− 0.23 ± 0.91	0.94
Medulla oblongata	0.16 ± 1.06	0.17 ± 0.95	0.84
Corpus callosum	− 0.15 ± 0.96	− 0.52 ± 1.04	0.22
CSF	0.72 ± 1.29	1.11 ± 1.19	0.34
Right ventricle	0.53 ± 1.12	1.05 ± 1.26	0.09
Left ventricle	0.41 ± 1.16	1.25 ± 1.33	0.042
Third ventricle	0.61 ± 1.14	1.37 ± 0.74	0.016
Fourth ventricle	0.15 ± 0.98	0.30 ± 1.43	0.97

Mean Z-score values and standard deviations are reported in this table, unless otherwise specified. CSF cerebrospinal fluid, GM gray matter, GMab abnormal gray matter in deep nuclei, WM white matter, WMab abnormal white matter

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