Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis

Cheung, Edward; Ahmad, Sarah; Aitken, Matthew; Chan, Rosanna; Iwanochko, Robert M.; Balter, Meyer; Metser, Ur; Veit-Haibach, Patrick; Billia, Filio; Moayedi, Yasbanoo; Ross, Heather J.; Hanneman, Kate

doi:10.1186/s41824-021-00119-w

EJNMMI Reports

Table 4 Univariable and multivariable time-to-event survival analysis for primary and secondary end-points

From: Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis

	Univariable			Multivariable
	HR (95% CI)	P value	AIC	HR (95% CI)	P value	AIC
MACE
Focal FDG uptake	10.8 (2.3, 51.2)	0.003	62	14.7 (2.8, 78.4)	0.002	56
Focal FDG uptake (number of segments)	1.2 (1.1, 1.4)	< 0.001	61	1.2 (1.1, 1.3)	0.004	62
CMV (10 cm³ increase)	1.2 (1.0, 1.3)	0.022	70	1.3 (1.1, 1.5)	0.006	64
Native T1 (100 ms increase)	2.2 (1.3, 3.6)	0.003	66	1.8 (1.0, 3.1)	0.044	66
ECV (1% increase)	1.1 (1.0, 1.1)	0.003	66	1.0 (0.99, 1.1)	0.07	67
Native T2 (10 ms increase)	3.9 (1.5, 10.2)	0.005	67	2.8 (1.0, 7.5)	0.041	66
Elevated T2	8.2 (2.2, 31.3)	0.002	63	9.0 (2.2, 37.7)	0.002	59
LVEF	0.93 (0.89, 0.98)	0.008	67	0.93 (0.88, 0.98)	0.008	69
Co-localized focal FDG uptake and LGE	11.8 (2.5, 55.6)	0.002	60	14.9 (2.8, 78.4)	0.001	56
Co-localized focal FDG uptake and high T1	11.8 (2.5, 55.6)	0.002	60	14.9 (2.8, 78.4)	0.001	56
Co-localized focal FDG uptake and high T2	6.0 (1.8, 20.8)	0.004	66	7.4 (2.0, 27.0)	0.003	61
NSVT
Focal FDG uptake	9.5 (2.0, 46.2)	0.005	57	12.0 (2.3, 63.1)	0.003	52
Focal FDG uptake (number of segments)	1.2 (1.1, 1.4)	< 0.001	54	1.2 (1.0, 1.3)	0.005	56
CMV (10 cm³ increase)	1.2 (1.0, 1.4)	0.026	63	1.3 (1.1, 1.5)	0.009	57
Native T1 (10 ms increase)	1.1 (1.0, 1.1)	0.003	59	1.1 (1.0, 1.1)	0.06	60
ECV (1% increase)	1.1 (1.0, 1.2)	0.002	58	1.1 (1.0, 1.1)	0.05	59
Native T2 (1 ms increase)	1.1 (1.0, 1.3)	0.008	61	1.1 (1.0, 1.2)	0.07	61
Elevated T2	7.1 (1.8, 27.8)	0.005	58	7.2 (1.7, 30.0)	0.007	55
LVEF	0.93 (0.88, 0.97)	0.007	59	0.93 (0.88, 0.98)	0.007	62
Co-localized focal FDG uptake and LGE	10.6 (2.2, 50.9)	0.003	56	12.3 (2.3, 63.0)	0.002	52
Co-localized focal FDG uptake and high T1	10.6 (2.2, 50.9)	0.003	56	12.3 (2.3, 63.0)	0.002	52
Co-localized focal FDG uptake and high T2	5.2 (1.5, 18.6)	0.011	61	7.2 (1.7, 30.0)	0.007	55

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