Articles

Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis

FDG-PET/CT is increasingly used for oncologic and inflammatory diseases. Focal incidental FDG uptake occurs rarely in breast tissue but has often significant consequences. This study aimed to systematically re...

Authors: Else Marie Aarstad, Petter Nordhaug, Mohammad Naghavi-Behzad, Lisbet Brønsro Larsen, Oke Gerke and Malene Grubbe Hildebrandt

Simultaneous ¹³N-Ammonia and gadolinium first-pass myocardial perfusion with quantitative hybrid PET-MR imaging: a phantom and clinical feasibility study

Positron emission tomography (PET) is the non-invasive reference standard for myocardial blood flow (MBF) quantification. Hybrid PET-MR allows simultaneous PET and cardiac magnetic resonance (CMR) acquisition ...

Authors: Muhummad Sohaib Nazir, Sarah-May Gould, Xenios Milidonis, Eliana Reyes, Tevfik F. Ismail, Radhouene Neji, Sébastien Roujol, Jim O’Doherty, Hui Xue, Sally F. Barrington, Tobias Schaeffter, Reza Razavi, Paul Marsden, Peter Kellman, Sven Plein and Amedeo Chiribiri

Assessment of a novel 32-channel phased array for cardiovascular hybrid PET/MRI imaging: MRI performance

Cardiovascular imaging using hybrid positron emission tomography (PET) and magnetic resonance imaging (MRI) requires a radio frequency phased array resonator capable of high acceleration factors in order to ac...

Authors: Adam Farag, R. Terry Thompson, Jonathan D. Thiessen, John Butler, Frank S. Prato and Jean Théberge

Characterization of the left ventricular arrhythmogenic substrate with multimodality imaging: role of innervation imaging and left ventricular global longitudinal strain

Even though implantable cardioverter defibrillator (ICD) implantation for primary prevention has shown to reduce the risk of sudden cardiac death in chronic heart failure patients with reduced left ventricular...

Authors: Mohammed El Mahdiui, Jeff M. Smit, Alexander R. van Rosendael, Victoria Delgado, Nina Ajmone Marsan, J. Wouter Jukema, Arthur J. H. A. Scholte and Jeroen J. Bax

Takayasu arteritis: clinical importance of extra-vessel uptake on FDG PET/CT

[F-18]fluorodeoxyglucose positron emission tomography/computed tomography is routinely used for assessing Takayasu arteritis patients. However, extra-vessel [F^-18]fluorodeoxyglucose uptake has not been evaluated ...

Authors: Junichi Tsuchiya, Daisuke Tezuka, Yasuhiro Maejima, Hyeyeol Bae, Takumi Oshima, Tomohiro Yoneyama, Kenzo Hirao, Mitsuaki Isobe and Ukihide Tateishi

EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras

An increasing number of Nuclear Medicine sites in Europe are using cardiac-centered gamma cameras for myocardial perfusion scintigraphy (MPS). Three cardiac-centered gamma cameras are currently the most freque...

Authors: Fabien Hyafil, Alessia Gimelli, Riemer H. J. A. Slart, Panagiotis Georgoulias, Christoph Rischpler, Mark Lubberink, Roberto Sciagra, Jan Bucerius, Denis Agostini and Hein J. Verberne

ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging

We investigated the clinical performance of a quantitative multi-modal SPECT/CT reconstruction platform for yielding radioactivity concentrations of bone imaging with ^99mTc-methylene diphosphonate (MDP) or ^99mTc-...

Authors: A. H. Vija, P. A. Bartenstein, J. W. Froelich, T. Kuwert, H. Macapinlac, C. P. Daignault, N. Gowda, O. Hadjiev, J. Hephzibah, P. Huang, H. Ilhan, A. Jessop, M. Cachovan, J. Ma, X. Ding, D. Spence…

Discrepancy between significant fibrosis and active inflammation in patients with cardiac sarcoidosis: combined and image fusion analysis of cardiac magnetic resonance and ¹⁸F fluorodeoxyglucose positron emission tomography

Diagnosis and evaluation of cardiac sarcoidosis (CS) are mainly based on the combined use of cardiac magnetic resonance imaging (CMR) and ¹⁸F fludeoxyglucose positron emission tomography (FDG). Though these modal...

Authors: Kenji Fukushima, Michinobu Nagao, Atsushi Yamamoto, Naoki Serizawa, Umiko Ishizaki, Atsushi Suzuki, Akiko Sakai, Eri Watanabe, Mitsuru Momose, Ichiei Kuji and Koichiro Abe

Hybrid FDG-PET/MR imaging of chronic osteomyelitis: a prospective case series

Magnetic resonance imaging (MRI) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography paired with computed tomography (PET/CT) are two commonly used imaging modalities in the complicated dia...

Authors: Dennis Jan Willem Hulsen, Jan Geurts, Jacobus J. Arts, Daan Loeffen, Cristina Mitea and Stefan Adrian Vöö

Does quantification have a role to play in the future of bone SPECT?

Routinely, there is a visual basis to nuclear medicine reporting: a reporter subjectively places a patient’s condition into one of multiple discrete classes based on what they see. The addition of a quantitati...

Authors: James C. Ross, Dijana Vilić, Tom Sanderson, Stefan Vöö and John Dickson

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

Authors: Philip Elsinga, Angelika Bischof Delaloye, Arturo Chiti, Stefaan Vandenberghe, Francesco Giammarile and Ignasi Carrio

Radionuclide imaging of inflammation in atherosclerotic vascular disease among people living with HIV infection: current practice and future perspective

People living with human immunodeficiency virus (HIV) infection have twice the risk of atherosclerotic vascular disease compared with non-infected individuals. Inflammation plays a critical role in the develop...

Authors: Ismaheel O. Lawal, Alfred O. Ankrah, Anton C. Stoltz and Mike M. Sathekge

Ability of artificial intelligence to diagnose coronary artery stenosis using hybrid images of coronary computed tomography angiography and myocardial perfusion SPECT

Detecting culprit coronary arteries in patients with ischemia using only myocardial perfusion single-photon emission computed tomography (SPECT) can be challenging. This study aimed to improve the detection of...

Authors: Hiroto Yoneyama, Kenichi Nakajima, Junichi Taki, Hiroshi Wakabayashi, Shinro Matsuo, Takahiro Konishi, Koichi Okuda, Takayuki Shibutani, Masahisa Onoguchi and Seigo Kinuya

Assessment of the kidney function parameters split function, mean transit time, and outflow efficiency using dynamic FDG-PET/MRI in healthy subjects

Traditionally, isotope nephrography is considered as the method of choice to assess kidney function parameters in nuclear medicine. We propose a novel approach to determine the split function (SF), mean transi...

Authors: Barbara K. Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker and Anton Staudenherz

Cardiac PET/MRI—an update

It is now about 8 years since the first whole-body integrated PET/MRI has been installed. First, reports on technical characteristics and system performance were published. Early after, reports on the first us...

Authors: C. Rischpler, S. G. Nekolla, G. Heusch, L. Umutlu, T. Rassaf, P. Heusch, K. Herrmann and F. Nensa

European Journal of Hybrid Imaging: the journey continues

Authors: Arturo Chiti and Francesco Giammarile

Tumor heterogeneity measurement using [¹⁸F] FDG PET/CT shows prognostic value in patients with non-small cell lung cancer

The aim of this study was to evaluate primary tumor heterogeneity in patients with FDG-avid non-small cell lung cancer on PET/CT, with a view to optimising prognostic information from the metabolic signature o...

Authors: N. M. Hughes, T. Mou, K. N. O’Regan, P. Murphy, J. N. O’Sullivan, E. Wolsztynski, J. Huang, M. P. Kennedy, J. F. Eary and F. O’Sullivan

Bone SPECT/CT imaging of a liposclerosing myxofibroid tumor in an unexpected localization

The combination of both functional and morphological information using three-phase bone scintigraphy and tomographic imaging with single photon emission tomography/computed tomography (SPECT/CT) allows precise...

Authors: Willm Uwe Kampen, Lidija Antunovic, Andreas M. Luebke, Guido Sauter, Klaus Strobel and Frederic Paycha

The prognostic value of preoperative FDG-PET/CT metabolic parameters in cervical cancer patients

To explore quantitative metabolic and microstructural primary tumour parameters at pretreatment FDG-PET/CT and diffusion-weighted-magnetic resonance imaging (DW-MRI) in relation to clinical FIGO stage and outc...

Authors: Vikram Rao Bollineni, Sigmund Ytre-Hauge, Ankush Gulati, Mari K. Halle, Kathrine Woie, Øyvind Salvesen, Jone Trovik, Camilla Krakstad and Ingfrid S. Haldorsen

Does addition of a diagnostic contrast-enhanced CT to a contemporaneous PET/CT provide incremental value in patients for restaging of colorectal carcinoma?

Both constrast-enhanced computed tomography (ceCT) and ¹⁸F-Fluorodeoxyglucose positron emission tomography (PET) are widely used for evaluation of colorectal cancer. Not infrequently patients undergo both tests, ...

Authors: Kenneth S. K. Yap, Ojas H. Mehta, Wing Fai Eddie Lau, Tim Akhurst, Satish Warrier, Alexander Heriot and Rodney J. Hicks

Incidental meningioma detected with [¹⁸F]-FDOPA PET/CT

A 59 year old patient was referred to our department to detect disease activity related to clinical symptoms of tiredness, weight loss and an elevated serum serotonine, suspicious of a neuro-endocrine tumour. ...

Authors: Gilles N. Stormezand, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart and Rudi A. J. O. Dierckx

Assessment of 18F-FDG uptake in idiopathic pulmonary fibrosis: influence of lung density changes

Idiopathic Pulmonary Fibrosis (IPF) is a progressive and irreversible disease leading to terminal respiratory insufficiency. Fluorodeoxyglucose ([18F]-FDG) PET/CT has been proposed to track the activity of the...

Authors: A. Castiaux, G. Van Simaeys, S. Goldman and B. Bondue

Occult capitate fracture through a bone island – SPECT/CT arthrography imaging

Single photon emission tomography/computed tomography (SPECT/CT) combines the strengths of bone scintigraphy and CT and serve as an important alternative to magnetic resonance (MR) imaging in carpal trauma patien...

Authors: Klaus Strobel, Lidija Antunovic, Wouter van der Bruggen, Gopinath Gnanasegaran, Willm Uwe Kampen, Tim Van den Wyngaert, Edmond Rust, Torsten Kuwert and Frédéric Paycha

¹⁸F-DCFPyL PET/CT in primary staging of prostate cancer

Correct primary staging is mandatory for therapy selection and to determine prognosis in prostate cancer patients. Commonly used diagnostic procedures including Computed Tomography (CT), Magnetic Resonance Ima...

Authors: Maurits Wondergem, Friso M van der Zant, Ton A Roeleveld, Sandra Srbljin, Marina S Kartachova, Annemarie van Dongen, Vera Franken and Remco J J Knol

Positron emission tomography in breast cancer: ¹⁸F- FDG and other radiopharmaceuticals

Breast cancer heterogeneity reflects the complex biology of this disease. Breast cancer subtypes, as identified either by immunohistochemistry (IHC) or by gene expression analysis, present different molecular ...

Authors: Ioannis Iakovou, Evanthia Giannoula, Areti Gkantaifi, Sofia Levva and Savvas Frangos

A prospective study determining and comparing the diagnostic accuracy of fluoride-PET/CT, choline-PET/CT, whole-body bone SPECT/CT and whole-body MRI for the detection of bone metastases in patients with prostate cancer

To determine and compare the diagnostic accuracy of fluoride-PET/CT (NaF-PET/CT), choline-PET/CT, whole-body bone SPECT/CT (WB-SPECT/CT) and whole-body MRI (WB-MRI) for the detection of bone metastases in pati...

Authors: Eva Dyrberg, Helle W. Hendel, Vibeke B. Løgager, Claus Madsen, Erik M. Pedersen, Bo Zerahn and Henrik S. Thomsen

Can ¹⁸F-fluorodeoxyglucose positron emission tomography predict the response to radioactive iodine therapy in metastatic differentiated thyroid carcinoma?

¹³¹I radioactive iodine therapy (RAI) has been commonly applied for metastatic differentiated thyroid cancer (DTC) and played an adjunctive role to total thyroidectomy. However, there is no reliable method to pre...

Authors: Xieyi Zhang, Tetsuya Higuchi, Arifudin Achmad, Anu Bhattarai, Hiroyasu Tomonaga, Huong Nguyen Thu, Aiko Yamaguchi, Hiromi Hirasawa, Ayako Taketomi-Takahashi and Yoshito Tsushima

Is hybrid SPECT/CT necessary for pre-interventional 3D quantification of relative lobar lung function?

In pulmonary malignancies pre-interventional 3D estimation of relative lobar perfusion is established to predict post-interventional functional outcome particularly in patients with borderline lung function. A...

Authors: Daniela Knollmann, Jerome Avondo and Wolfgang M. Schaefer

Tc-HDP quantitative SPECT/CT in transthyretin cardiac amyloid and the development of a reference interval for myocardial uptake in the non-affected population

99mTechnetium-HDP (HDP) bone scans differentiate transthyretin (ATTR) cardiac amyloid from other infiltrative myocardial diseases. These scans are not quantitative and are assessed by comparing myocardial upta...

Authors: Stuart C. Ramsay, Karen Lindsay, William Fong, Shaun Patford, John Younger and John Atherton

Pre-treatment ¹⁸F-choline PET/CT is prognostic for biochemical recurrence, development of bone metastasis, and cancer specific mortality following radical local therapy of high-risk prostate cancer

The aim of this study was to determine whether lymph node metastasis on pre-treatment ¹⁸F-choline PET/CT is an independent prognostic factor for biochemical recurrence (BCR), skeletal metastasis, and cancer speci...

Authors: Henrik Kjölhede, Helén Almquist, Kerstin Lyttkens and Ola Bratt

The machine learning horizon in cardiac hybrid imaging

Machine learning (ML) represents a family of algorithms that has rapidly developed within the last years in a wide variety of knowledge areas. ML is able to elucidate and grasp complex patterns from data in or...

Authors: Luis Eduardo Juarez-Orozco, Octavio Martinez-Manzanera, Sergey V. Nesterov, Sami Kajander and Juhani Knuuti

Added value of ¹⁸F-FDG PET-CT in staging of Ewing sarcoma in children and young adults

Ewing sarcoma (ES) is currently staged using Radiography, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and skeletal scintigraphy (bone scan). ¹⁸F- fluorodeoxyglucose Positron Emission To...

Authors: Boel Johnsen, Kristine Eldevik Fasmer, Kjetil Boye, Karen Rosendahl, Clement Trovik, Martin Biermann and Stein Magnus Aukland

PET/MRI: a frontier in era of complementary hybrid imaging

With primitive approaches, the diagnosis and therapy were operated at the cellular, molecular, or even at the genetic level. As the diagnostic techniques are more concentrated towards molecular level, multi mo...

Authors: Sikkandhar Musafargani, Krishna Kanta Ghosh, Sachin Mishra, Pachaiyappan Mahalakshmi, Parasuraman Padmanabhan and Balázs Gulyás

Myocardial blood flow and myocardial flow reserve values in ¹³N–ammonia myocardial perfusion PET/CT using a time-efficient protocol in patients without coronary artery disease

Cardiac imaging by means of myocardial Positron Emission Tomography/Computed Tomography (PET/CT) is being used increasingly to assess coronary artery disease, to guide revascularization decisions with more acc...

Authors: Opstal TSJ, Knol RJJ, Cornel JH, Wondergem M and van der Zant FM

Interpreting ¹²³I–ioflupane dopamine transporter scans using hybrid scores

Dopamine transporter (DaT) ¹²³I–FP-CIT scans most commonly are interpreted visually. Alternatively, absolute quantitation of radiopharmaceutical uptake may improve scan accuracy. However, neither approach accomod...

Authors: Kenneth J. Nichols, Brandon Chen, Maria B. Tomas and Christopher J. Palestro

⁶⁸Ga-PSMA and ¹¹C-Choline comparison using a tri-modality PET/CT-MRI (3.0 T) system with a dedicated shuttle

The aim of this study was to prospectively compare the detection rate of ⁶⁸Ga-PSMA versus ¹¹C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality P...

Authors: Omar Alonso, Gerardo dos Santos, Margarita García Fontes, Henia Balter and Henry Engler

Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)

Positron emission tomography (PET) and magnetic resonance imaging (MRI) have both been used for decades in cardiovascular imaging. Since 2010, hybrid PET/MRI using sequential and integrated scanner platforms h...

Authors: Felix Nensa, Fabian Bamberg, Christoph Rischpler, Leon Menezes, Thorsten D. Poeppel, Christian la Fougère, Dietrich Beitzke, Sazan Rasul, Christian Loewe, Konstantin Nikolaou, Jan Bucerius, Andreas Kjaer, Matthias Gutberlet, Niek H. Prakken, Rozemarijn Vliegenthart, Riemer H. J. A. Slart…

The role of hybrid bone SPECT/CT imaging in the work-up of the limping patient: a symptom-based and joint-oriented review

A vast spectrum of lower limb bone and joint disorders (hip, knee, ankle, foot) present with a common clinical presentation: limping. Too often this symptom generates an inefficient cascade of imaging studies.

Authors: H. K. Mohan, K. Strobel, W. van der Bruggen, G. Gnanasegaran, W. U. Kampen, T. Kuwert, T. Van den Wyngaert and F. Paycha

Low dose radiation 18F–fluoride PET/CT in the assessment of Unilateral Condylar Hyperplasia of the mandible: preliminary results of a single centre experience

Unilateral condylar hyperplasia (UCH) of the mandible, or Hypercondylia, is a pathological condition that determines an abnormal growth of the affected condyle.

Authors: G. M. Lima, S. Diodato, E. Costabile, G. Cicoria, S. Civollani, C. Marchetti, P. L. Guidalotti, C. Pettinato, C. Nanni and S. Fanti

The clinical value of xSPECT/CT Bone versus SPECT/CT. A prospective comparison of 200 scans

To prospectively evaluate the clinical utility of xSPECT/CT Bone, a new reconstruction algorithm for single photon emission tomography (SPECT), and compare it with standard SPECT/CT reconstruction.

Authors: Iain Duncan and Nicholas Ingold

Diagnostic performance of hybrid cardiac SPECT/CT imaging for patients with takotsubo cardiomyopathy

The diagnostic performance of SPECT-only imaging for takotsubo cardiomyopathy (TC) is limited due to the lack of coronary artery distribution information. The aim of this study was to evaluate the diagnostic p...

Authors: Yasuro Sugihara, Yoshimitsu Fukushima, Shin-ichiro Kumita, Hitoshi Takano and Wataru Shimizu

Ground glass pulmonary nodules: their significance in oncology patients and the role of computer tomography and 18F–fluorodeoxyglucose positron emission tomography

to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancie...

Authors: Laura Evangelista, Annalori Panunzio, Elena Scagliori and Paolo Sartori

Prevalence and prognostic value of increased uptake in bone SPECT/CT in asymptomatic wrists

To evaluate the prevalence and prognostic value of increased uptake in SPECT/CT in asymptomatic wrists.

Authors: Maresa Allgayer, Urs Hug, Justus Egidius Roos, Maria del Sol Pérez Lago, Damian Wild, Dirk Lehnick and Klaus Strobel

¹⁸F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab

¹⁸F–FDG PET/CT has been proposed in the evaluation of the disease activity in rheumatoid arthritis (RA). The goals of this study were to evaluate the reproducibility of the technique, to compare metabolic parame....

Authors: Pacôme FOSSE, Marie-Joelle KAISER, Gauthier NAMUR, Dominique de Seny, Michel G. MALAISE and Roland HUSTINX

Trends in oncologic hybrid imaging

Hybrid imaging plays a central role in the diagnosis and management of a wide range of malignancies at all stages. In this article, we review the most pertinent historical developments, emerging clinical appli...

Authors: Andreas G. Wibmer, Hedvig Hricak, Gary A. Ulaner and Wolfgang Weber

Somatostatin receptor based hybrid imaging in sarcoidosis

Several diagnostic imaging methodologies are available for the clinical evaluation of sarcoidosis, but all have their limitations. FDG PET/CT is frequently used, but this technique does not provide optimal res...

Authors: Riemer H. J. A. Slart, Klaas-Pieter Koopmans, Peter Paul van Geel, Henk Kramer, Harry J. M. Groen, C. Tji-Joong Gan, Niek H. J. Prakken, Andor W. J. M. Glaudemans and George D. Nossent

Perfusion CT and PET with 18F–FDG and 18F–FCh in the complex diagnosis of hepatocellular carcinoma

The purpose of the study to evaluate possibilities of CT-perfusion and PET methods with 18F–FDG and 18F–fluorocholine in the complex diagnosis of hepatocellular carcinoma. The study included the results of PET...

Authors: P. E. Tulin, M. B. Dolgushin, A. A. Odzharova, A. I. Mikhaylov, B. M. Medvedeva, S. V. Shiryaev and B. I. Dolgushin

Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation

TNM Stage 3B encompasses a wide range of primary tumor and nodal metastatic tumor burden. This study aimed to evaluate the prognostic value of quantitative FDG PET/CT parameters in patients with newly diagnose...

Authors: Brittany Z. Dashevsky, Chenpeng Zhang, Li Yan, Cindy Yuan, Lingyun Xiong, Yongmei Liu, Haiyan Liu, Feng-Ming Spring Kong and Yonglin Pu

A population-based study of the clinical utility of ¹⁸F–choline PET/CT for primary metastasis staging of high-risk prostate cancer

The clinical utility of ¹⁸F–choline positron emission tomography fused with computed tomography (PET/CT) in all men with high-risk prostate cancer is still uncertain, because of selection of patients in previous ...

Authors: Henrik Kjölhede, Helen Almquist, Kerstin Lyttkens and Ola Bratt

Multiparametric 18F–FDG PET/MR follow-up in a patient with autoimmune pancreatitis

Positron emission tomography/magnetic resonance imaging (PET/MR) is a new multimodal imaging technique, which might improve the diagnostic performance not only in oncological patients but also in patients with...

Authors: Isabel Rauscher, Matthias Eiber, Hana Algül, Jens T. Siveke, Gregor Weirich, Anna M. Schlitter and Ambros J. Beer