Articles

A prospective study determining and comparing the diagnostic accuracy of fluoride-PET/CT, choline-PET/CT, whole-body bone SPECT/CT and whole-body MRI for the detection of bone metastases in patients with prostate cancer

To determine and compare the diagnostic accuracy of fluoride-PET/CT (NaF-PET/CT), choline-PET/CT, whole-body bone SPECT/CT (WB-SPECT/CT) and whole-body MRI (WB-MRI) for the detection of bone metastases in pati...

Authors: Eva Dyrberg, Helle W. Hendel, Vibeke B. Løgager, Claus Madsen, Erik M. Pedersen, Bo Zerahn and Henrik S. Thomsen

Can ¹⁸F-fluorodeoxyglucose positron emission tomography predict the response to radioactive iodine therapy in metastatic differentiated thyroid carcinoma?

¹³¹I radioactive iodine therapy (RAI) has been commonly applied for metastatic differentiated thyroid cancer (DTC) and played an adjunctive role to total thyroidectomy. However, there is no reliable method to pre...

Authors: Xieyi Zhang, Tetsuya Higuchi, Arifudin Achmad, Anu Bhattarai, Hiroyasu Tomonaga, Huong Nguyen Thu, Aiko Yamaguchi, Hiromi Hirasawa, Ayako Taketomi-Takahashi and Yoshito Tsushima

Is hybrid SPECT/CT necessary for pre-interventional 3D quantification of relative lobar lung function?

In pulmonary malignancies pre-interventional 3D estimation of relative lobar perfusion is established to predict post-interventional functional outcome particularly in patients with borderline lung function. A...

Authors: Daniela Knollmann, Jerome Avondo and Wolfgang M. Schaefer

Tc-HDP quantitative SPECT/CT in transthyretin cardiac amyloid and the development of a reference interval for myocardial uptake in the non-affected population

99mTechnetium-HDP (HDP) bone scans differentiate transthyretin (ATTR) cardiac amyloid from other infiltrative myocardial diseases. These scans are not quantitative and are assessed by comparing myocardial upta...

Authors: Stuart C. Ramsay, Karen Lindsay, William Fong, Shaun Patford, John Younger and John Atherton

Pre-treatment ¹⁸F-choline PET/CT is prognostic for biochemical recurrence, development of bone metastasis, and cancer specific mortality following radical local therapy of high-risk prostate cancer

The aim of this study was to determine whether lymph node metastasis on pre-treatment ¹⁸F-choline PET/CT is an independent prognostic factor for biochemical recurrence (BCR), skeletal metastasis, and cancer speci...

Authors: Henrik Kjölhede, Helén Almquist, Kerstin Lyttkens and Ola Bratt

The machine learning horizon in cardiac hybrid imaging

Machine learning (ML) represents a family of algorithms that has rapidly developed within the last years in a wide variety of knowledge areas. ML is able to elucidate and grasp complex patterns from data in or...

Authors: Luis Eduardo Juarez-Orozco, Octavio Martinez-Manzanera, Sergey V. Nesterov, Sami Kajander and Juhani Knuuti

Added value of ¹⁸F-FDG PET-CT in staging of Ewing sarcoma in children and young adults

Ewing sarcoma (ES) is currently staged using Radiography, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and skeletal scintigraphy (bone scan). ¹⁸F- fluorodeoxyglucose Positron Emission To...

Authors: Boel Johnsen, Kristine Eldevik Fasmer, Kjetil Boye, Karen Rosendahl, Clement Trovik, Martin Biermann and Stein Magnus Aukland

PET/MRI: a frontier in era of complementary hybrid imaging

With primitive approaches, the diagnosis and therapy were operated at the cellular, molecular, or even at the genetic level. As the diagnostic techniques are more concentrated towards molecular level, multi mo...

Authors: Sikkandhar Musafargani, Krishna Kanta Ghosh, Sachin Mishra, Pachaiyappan Mahalakshmi, Parasuraman Padmanabhan and Balázs Gulyás

Myocardial blood flow and myocardial flow reserve values in ¹³N–ammonia myocardial perfusion PET/CT using a time-efficient protocol in patients without coronary artery disease

Cardiac imaging by means of myocardial Positron Emission Tomography/Computed Tomography (PET/CT) is being used increasingly to assess coronary artery disease, to guide revascularization decisions with more acc...

Authors: Opstal TSJ, Knol RJJ, Cornel JH, Wondergem M and van der Zant FM

Interpreting ¹²³I–ioflupane dopamine transporter scans using hybrid scores

Dopamine transporter (DaT) ¹²³I–FP-CIT scans most commonly are interpreted visually. Alternatively, absolute quantitation of radiopharmaceutical uptake may improve scan accuracy. However, neither approach accomod...

Authors: Kenneth J. Nichols, Brandon Chen, Maria B. Tomas and Christopher J. Palestro

⁶⁸Ga-PSMA and ¹¹C-Choline comparison using a tri-modality PET/CT-MRI (3.0 T) system with a dedicated shuttle

The aim of this study was to prospectively compare the detection rate of ⁶⁸Ga-PSMA versus ¹¹C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality P...

Authors: Omar Alonso, Gerardo dos Santos, Margarita García Fontes, Henia Balter and Henry Engler

Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)

Positron emission tomography (PET) and magnetic resonance imaging (MRI) have both been used for decades in cardiovascular imaging. Since 2010, hybrid PET/MRI using sequential and integrated scanner platforms h...

Authors: Felix Nensa, Fabian Bamberg, Christoph Rischpler, Leon Menezes, Thorsten D. Poeppel, Christian la Fougère, Dietrich Beitzke, Sazan Rasul, Christian Loewe, Konstantin Nikolaou, Jan Bucerius, Andreas Kjaer, Matthias Gutberlet, Niek H. Prakken, Rozemarijn Vliegenthart, Riemer H. J. A. Slart…

The role of hybrid bone SPECT/CT imaging in the work-up of the limping patient: a symptom-based and joint-oriented review

A vast spectrum of lower limb bone and joint disorders (hip, knee, ankle, foot) present with a common clinical presentation: limping. Too often this symptom generates an inefficient cascade of imaging studies.

Authors: H. K. Mohan, K. Strobel, W. van der Bruggen, G. Gnanasegaran, W. U. Kampen, T. Kuwert, T. Van den Wyngaert and F. Paycha

Low dose radiation 18F–fluoride PET/CT in the assessment of Unilateral Condylar Hyperplasia of the mandible: preliminary results of a single centre experience

Unilateral condylar hyperplasia (UCH) of the mandible, or Hypercondylia, is a pathological condition that determines an abnormal growth of the affected condyle.

Authors: G. M. Lima, S. Diodato, E. Costabile, G. Cicoria, S. Civollani, C. Marchetti, P. L. Guidalotti, C. Pettinato, C. Nanni and S. Fanti

The clinical value of xSPECT/CT Bone versus SPECT/CT. A prospective comparison of 200 scans

To prospectively evaluate the clinical utility of xSPECT/CT Bone, a new reconstruction algorithm for single photon emission tomography (SPECT), and compare it with standard SPECT/CT reconstruction.

Authors: Iain Duncan and Nicholas Ingold

Diagnostic performance of hybrid cardiac SPECT/CT imaging for patients with takotsubo cardiomyopathy

The diagnostic performance of SPECT-only imaging for takotsubo cardiomyopathy (TC) is limited due to the lack of coronary artery distribution information. The aim of this study was to evaluate the diagnostic p...

Authors: Yasuro Sugihara, Yoshimitsu Fukushima, Shin-ichiro Kumita, Hitoshi Takano and Wataru Shimizu

Ground glass pulmonary nodules: their significance in oncology patients and the role of computer tomography and 18F–fluorodeoxyglucose positron emission tomography

to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancie...

Authors: Laura Evangelista, Annalori Panunzio, Elena Scagliori and Paolo Sartori

Prevalence and prognostic value of increased uptake in bone SPECT/CT in asymptomatic wrists

To evaluate the prevalence and prognostic value of increased uptake in SPECT/CT in asymptomatic wrists.

Authors: Maresa Allgayer, Urs Hug, Justus Egidius Roos, Maria del Sol Pérez Lago, Damian Wild, Dirk Lehnick and Klaus Strobel

¹⁸F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab

¹⁸F–FDG PET/CT has been proposed in the evaluation of the disease activity in rheumatoid arthritis (RA). The goals of this study were to evaluate the reproducibility of the technique, to compare metabolic parame....

Authors: Pacôme FOSSE, Marie-Joelle KAISER, Gauthier NAMUR, Dominique de Seny, Michel G. MALAISE and Roland HUSTINX

Trends in oncologic hybrid imaging

Hybrid imaging plays a central role in the diagnosis and management of a wide range of malignancies at all stages. In this article, we review the most pertinent historical developments, emerging clinical appli...

Authors: Andreas G. Wibmer, Hedvig Hricak, Gary A. Ulaner and Wolfgang Weber

Somatostatin receptor based hybrid imaging in sarcoidosis

Several diagnostic imaging methodologies are available for the clinical evaluation of sarcoidosis, but all have their limitations. FDG PET/CT is frequently used, but this technique does not provide optimal res...

Authors: Riemer H. J. A. Slart, Klaas-Pieter Koopmans, Peter Paul van Geel, Henk Kramer, Harry J. M. Groen, C. Tji-Joong Gan, Niek H. J. Prakken, Andor W. J. M. Glaudemans and George D. Nossent

Perfusion CT and PET with 18F–FDG and 18F–FCh in the complex diagnosis of hepatocellular carcinoma

The purpose of the study to evaluate possibilities of CT-perfusion and PET methods with 18F–FDG and 18F–fluorocholine in the complex diagnosis of hepatocellular carcinoma. The study included the results of PET...

Authors: P. E. Tulin, M. B. Dolgushin, A. A. Odzharova, A. I. Mikhaylov, B. M. Medvedeva, S. V. Shiryaev and B. I. Dolgushin

Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation

TNM Stage 3B encompasses a wide range of primary tumor and nodal metastatic tumor burden. This study aimed to evaluate the prognostic value of quantitative FDG PET/CT parameters in patients with newly diagnose...

Authors: Brittany Z. Dashevsky, Chenpeng Zhang, Li Yan, Cindy Yuan, Lingyun Xiong, Yongmei Liu, Haiyan Liu, Feng-Ming Spring Kong and Yonglin Pu

A population-based study of the clinical utility of ¹⁸F–choline PET/CT for primary metastasis staging of high-risk prostate cancer

The clinical utility of ¹⁸F–choline positron emission tomography fused with computed tomography (PET/CT) in all men with high-risk prostate cancer is still uncertain, because of selection of patients in previous ...

Authors: Henrik Kjölhede, Helen Almquist, Kerstin Lyttkens and Ola Bratt

Multiparametric 18F–FDG PET/MR follow-up in a patient with autoimmune pancreatitis

Positron emission tomography/magnetic resonance imaging (PET/MR) is a new multimodal imaging technique, which might improve the diagnostic performance not only in oncological patients but also in patients with...

Authors: Isabel Rauscher, Matthias Eiber, Hana Algül, Jens T. Siveke, Gregor Weirich, Anna M. Schlitter and Ambros J. Beer

18F–FDG PET/CT scan confirmed by pathology findings in a singular case of squamous cell carcinoma of the epiglottis

Only about 1% of all head and neck lateral or paramedian cancers described in the scientific literature shows, in staging, contralateral cervical adenopathy without ipsilateral pathological involvement of lymp...

Authors: G. M. Lima, A. Matti, L. Burgio, C. Nanni, P. Castellucci and S. Fanti

An artefact of PET attenuation correction caused by iron overload of the liver in clinical PET-MRI

Attenuation correction is one of the most important steps in producing quantitative PET image data. In hybrid PET-MRI systems, this correction is far from trivial, as MRI data are not correlated to PET attenua...

Authors: Florian Büther, Benjamin Noto, Katharina Auf der Springe, Thomas Allkemper and Lars Stegger

Targeted 11C–choline PET-CT/TRUS software fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI after previous negative biopsy

We evaluated the feasibility and accuracy of 11C–choline PET-CT/TRUS fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or contraindication to MRI, after previous negative b...

Authors: Massimo Lazzeri, Egesta Lopci, Giovanni Lughezzani, Piergiuseppe Colombo, Paolo Casale, Rodolfo Hurle, Alberto Saita, Lorenzo Leonardi, Giuliana Lista, Roberto Peschechera, Luisa Pasini, Marcello Rodari, Silvia Zandegiacomo, Alessio Benetti, Pasquale Cardone, Federica Mrakic…

A new member in the EJNMMI family: the European Journal of Hybrid Imaging

Authors: Arturo Chiti

Interpretation of 11C–choline PET/CT for the diagnosis of local relapse in radically treated prostate cancer

11C–choline PET/CT is a widely-used tool for the diagnostic of prostate cancer (PCa). In literature, a great variability of local relapse (LR) detection rate is reported. The aim of this study is to provide po...

Authors: A. Matti, G. M. Lima, L. Zanoni, C. Pultrone, R. Schiavina, F. Lodi, S. Fanti and C. Nanni

Feasibility of simultaneous PET-MR perfusion using a novel cardiac perfusion phantom

PET-MR scanners are beginning to be employed for quantitative myocardial perfusion imaging. In order to examine simultaneous perfusion calculations, this work describes a feasibility study of simultaneous PET-...

Authors: Jim O’Doherty, Eva Sammut, Paul Schleyer, James Stirling, Muhummad Sohaib Nazir, Paul K. Marsden and Amedeo Chiribiri

[¹⁸F]FDG-PET/CT texture analysis in thyroid incidentalomas: preliminary results

significance of incidental thyroid 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) uptake on positron emission tomography/computed tomography (PET/CT) scans remains controversial. We aimed to evaluate the ability of [

Authors: M. Sollini, L. Cozzi, G. Pepe, L. Antunovic, A. Lania, L. Di Tommaso, P. Magnoni, P. A. Erba and M. Kirienko

Skeletal standardized uptake values obtained by quantitative SPECT/CT as an osteoblastic biomarker for the discrimination of active bone metastasis in prostate cancer

To investigate the improvement of prognostication of active bone metastatic burden by discriminating bone metastases from degenerative changes in hot foci, using skeletal standardized uptake values (SUVs) by q...

Authors: Ichiei Kuji, Tomohiko Yamane, Akira Seto, Yota Yasumizu, Suguru Shirotake and Masafumi Oyama